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Anticancer effects of the p53 activator nutlin-3 in Ewing’s sarcoma cells

✍ Scribed by Jürgen Sonnemann; Chithra D. Palani; Susan Wittig; Sabine Becker; Friederike Eichhorn; Astrid Voigt; James F. Beck

Book ID
116430671
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
395 KB
Volume
47
Category
Article
ISSN
0959-8049

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## Abstract Ewing sarcoma (ES), a highly malignant pediatric tumor, is consistently associated with translocations that fuse the EWS gene with a member of the ETS family gene, most commonly FLI‐1. Despite significant advances with multiagent chemotherapy, surgery and radiotherapy, about 40% of ES p