Adult T-cell leukernidlymphoma (ATL), a malignancy of mature CDCpositive lymphocytes, has been etiologically linked to the human retrovirus HTLV-I. Although a long latent period is suggested from migrant studies, little prospective information on the risk of developing ATL among persons with HTLV-I
Antibody to the central region of human T-lymphotropic virus type 1 gp46 is associated with the progression of adult T-cell leukemia
β Scribed by Yasuko Sagara; Yukiko Inoue; Koichi Ohshima; Eijiro Kojima; Atae Utsunomiya; Mitsushi Tsujimura; Hiroshi Shiraki; Seizaburo Kashiwagi
- Book ID
- 108583794
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 303 KB
- Volume
- 98
- Category
- Article
- ISSN
- 1347-9032
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In order to shed light on the mode of HTLV-I infection by mother-to-child transmission, we examined sera of school children in a highly endemic town on two separate occasions at a 6-year interval. The carrier rates in ages 15-17, 8.7 and 2.1%, were significantly higher than that in ages 6-8, 1.7 and
Paired sera, saliva and cervicovaginal secretions from 17 HTLV-I-infected women (19-75 yr) were tested for total IgA and IgG, for IgA and IgG to the immunodominant region gp46/175-Pro-199, for serum IgG to the neutralizing domains gp46/ 190-Pro-I99 and gp46/190-Ser-199, or for tax-rex proviral HTLV-