The prevalence of antibodies against HIV-1 regulatory proteins in sera of HIV-infected patients from different stages of disease was investigated. HIV-1 vif, tat, and nef genes were cloned in procaryotic vectors and were expressed as MS-2 fusion proteins (vif and nef) or as a non-fusion protein (tat
Antibody to HIV-1 Tat protein inhibits the replication of virus in culture
✍ Scribed by L. Steinaa; A. M. Sørensen; J. O. Nielsen; J. E. S. Hansen
- Publisher
- Springer Vienna
- Year
- 1994
- Tongue
- English
- Weight
- 728 KB
- Volume
- 139
- Category
- Article
- ISSN
- 1432-8798
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The tat regulatory protein of HIV-1 was expressed as a fusion protein in E. coli and used as antigen to detect antibodies against HIV-tat (anti-tat) in the serum of HIV-1 infected children and adults. HIV-1-infected children showed a higher frequency (55%) of anti-tat than HIV-1-infected adults (36%
## Abstract The high incidence of progressive multifocal leukoencephalopathy (PML) among individuals with acquired immunodeficiency syndrome (AIDS) is similar to the incidence of other immunocompromised diseases. The pathogenic JC virus (JCV) with rearranged regulatory regions (PML‐type) causes PML