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Antibody to Epstein-Barr virus-specific DNase as a marker for the early detection of nasopharyngeal carcinoma

✍ Scribed by Jen-Yang Chen; Mei-Ying Liu; Chien-Jen Chen; Mow-Ming Hsu; Shih-Mien Tu; Hong-Hsin Lee; Shiow-Ling Kuo; Czau-Siung Yang

Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
180 KB
Volume
17
Category
Article
ISSN
0146-6615

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✦ Synopsis

We have previously shown that high levels of antibody to Epstein-Barr virus (EBV)-specific DNase may be a useful marker for the early diagnosis of nasopharyngeal carcinoma (NPC). Sera from 3,368 males in an area with a high risk for the development of NPC were examined for the presence of antibody to EBV-specific DNase activity. Significant levels of the antibody were found in 430 of these sera. As a result, 32 individuals have attended the out-patient department of otolaryngology for clinical examination. Among them, one individual was found to have a stage II nasopharyngeal carcinoma. This result supports the value of determination of antibody to EBV-specific DNase as a marker for the early detection of NPC.

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