Antibody response to poliovirus immunization in childhood leukemia
โ Scribed by Bosu, S. K. ;Ciudad, Hernan ;Sinks, Lucius F. ;Ogra, Pearay I.
- Publisher
- John Wiley and Sons
- Year
- 1975
- Tongue
- English
- Weight
- 356 KB
- Volume
- 1
- Category
- Article
- ISSN
- 0098-1532
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โฆ Synopsis
Abstract
Polio antibody titers were determined in 29 children with ALL in various clinical stages, including a group of five patients in continuous remission for over five years and who, at the time of study, were off all therapy for at least six months. Regardless of the stage of disease, no detectable YM response was elicited. The five children described above displayed the same depressed response as did the other children with ALL. This strongly suggests an inherent defect in the immune system of these children with ALL unrelated to therapy.
๐ SIMILAR VOLUMES
Antibody responses were studied in ยฎve groups of children immunized with different three-dose schedules of inactivated poliovirus vaccine (IPV). The age of the child at the ยฎrst dose (1ยฑ4 months) and the interval between the ยฎrst and second doses (2ยฑ4 months) inยฏuenced the initial responses in a ser
## Abstract A total of 32 unimmunized children (median age 5 months) living in an orphanage in Minsk, Belarus, were vaccinated with three doses of oral poliovirus vaccine (OPV) with a 60โday interval between the doses. Blood samples were drawn before the immunizations and 45โ50 days after each vacc
The objective of this study was to determine in children with acute lym phocytic leukemia (ALL) whether prolonged remission could be attained following relapse from prior chemotherapy. Multiple agent chemotherapy and central nervous system radiotherapy were administered to 16 children who had had on