Age- and dose-interval-dependent antibody responses to inactivated poliovirus vaccine

✍ Scribed by H. Sormunen; M. Stenvik; J. Eskola; T. Hovi

• Publisher: John Wiley and Sons
• Year: 2001
• Tongue: English
• Weight: 123 KB
• Volume: 63
• Category: Article
• ISSN: 0146-6615
• DOI: 10.1002/1096-9071(200104)63:4<305::aid-jmv1006>3.0.co;2-u

✦ Synopsis

Antibody responses were studied in ®ve groups of children immunized with different three-dose schedules of inactivated poliovirus vaccine (IPV). The age of the child at the ®rst dose (1±4 months) and the interval between the ®rst and second doses (2±4 months) in¯uenced the initial responses in a serotype-dependent manner. All the groups attained suf®cient antibody level after three doses but the third dose given at 18 months resulted in higher persisting antibody levels than that given at 12 months. The highest persisting antibody titers against PV1 and PV2 (but not against PV3) at the age of 3 years were measured in the control group immunized with the current schedule (P `0X001) in which the ®rst dose is given at 6 months. The level of maternal antibodies present at the time of the ®rst dose correlated negatively with the antibody titers as late as at 3 years of age. It is concluded that three doses of IPV given in widely variable schedules may result in satisfactory immune responses in children but, for optimal results, very early onset of the program and short dosage intervals should be avoided.