𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Antibodies to liposomes, phospholipids and phosphate esters

✍ Scribed by Carl R. Alving

Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
624 KB
Volume
40
Category
Article
ISSN
0009-3084

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✦ Synopsis

Polyclonal and monoclonal antibodies to liposomes having various phospholipid compositions have been produced. Binding of the anti-lipid bilayer antibodies is influenced both by the chemical composition and the physical state of the liposomal lipids. The antibodies to liposomes have a 'subsite' in the binding site that recognizes small soluble phosphorylated haptens such as nucleotides (e.g., ATP). The capacity of anti-liposome ant~odies to bind to phosphate is also shared by ant~odies to numerous other substances, including lipid A from Gram-negative bacterial lipopolysaccharide, cardiolipin, DNA, polynucleotides, and lipoteichoic acids from Gram-positive bacteria, Because of similarities of chemical structures between all of these molecules widespread immunological cross-reactivities are observed.

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