Antibodies Raised Against the Second Extracellular Loop of the Human Muscarinic M3 Receptor Mimic Functional Autoantibodies in Sjögren's Syndrome
✍ Scribed by D. Cavill; S. A. Waterman; T. P. Gordon
- Book ID
- 110749529
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 100 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0300-9475
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## Abstract ## Objective Sjögren's syndrome (SS) is an autoimmune disease affecting primarily the salivary and lacrimal glands, leading to dry mouth and dry eyes. Recent studies have suggested that autoantibodies reactive with the type 3 muscarinic acetylcholine receptors (M3Rs) expressed on saliv
The effects of anti-peptide antibodies against the second extracellular loop of human M2 muscarinic receptor on transmembrane potentials and currents in guinea pig single ventricular cells were analyzed using whole-cell patch clamp technique. These effects were compared with those of the muscarinic