Antibodies against polypeptides of purified Epstein-Barr virus in sera from patients with connective tissue diseases
β Scribed by Ngou, Jean; Graafland, Hubert; Segondy, Michel
- Book ID
- 123249740
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 496 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0896-8411
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π SIMILAR VOLUMES
A salt-dependent DNA polymerase activity was demonstrated in the culture of an EBV-producing, lymphoblastoid cell line (NPC-204 cells) treated with 5-iodo-2'-deoxyuridine (IUdR). There was a high frequency of levels of antibody to this enzyme in sera of patients with nasopharyngeal carcinoma (NPC).
The Epstein-Barr virus (EBV) is a ubiquitous Herpes virus which causes infectious mononucleosis and is associated with such different neoplasms as Burkitt's lymphoma and nasopharyngeal carcinoma. EBV latently infects its target cells; nevertheless, evidence of viral replication in NPC tumours has be