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Antibodies against cytokeratin 8/18 in a patient with de novo autoimmune hepatitis after living-donor liver transplantation

✍ Scribed by Ayano Inui; Tsuyoshi Sogo; Haruki Komatsu; Hiroshi Miyakawa; Tomoo Fujisawa

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 83 KB
Volume: 11
Category: Article
ISSN: 1527-6465
DOI: 10.1002/lt.20404

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✦ Synopsis

Graft dysfunction mimicking autoimmune hepatitis rarely develops after liver transplantation for nonautoimmune disease. The mechanism(s) and causes of de novo autoimmune hepatitis are unknown. We examined autoantibodies serially in a patient with de novo autoimmune hepatitis and in patients without de novo autoimmune hepatitis after liver transplantation. Anticytokeratin 8/18 antibodies were detected in the first patient's sera after the onset of de novo autoimmune hepatitis, whereas other patients without de novo autoimmune hepatitis were seronegative throughout the follow-up period even with acute cellular rejection or other cause of liver dysfunction. In conclusion, the changes in cytokeratin 8/18 in hepatocytes might be one of the sources of pathogenesis of de novo autoimmune hepatitis after liver transplantation. (Liver

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