Antibiotics immobilized on polysaccharides

✍ Scribed by Simionescu, Cristofor I. ;Dumitriu, Severian ;Popa, Marcel I. ;Denisova, Ludmila

• Publisher: Wiley (John Wiley & Sons)
• Year: 1985
• Weight: 394 KB
• Volume: 9
• Category: Article
• ISSN: 0025-116X
• DOI: 10.1002/macp.1985.020091985126

✦ Synopsis

The coupling of oxytetracycline to the diazonium salt of 4-aminobenzoylcellulose, of ampicillin and chloramphenicol to Biozan R and of 7-aminocephlosporanic acid ( 7 -A C S ) t o carboxymethylcellulose (CMC) and t o N-(4-~arboxyphenyl)carbamoylmethyl cellulose (N-CPhCMC) are presented. The amount of bound oxytetracycline is dependent on reaction time and structure of the substrate. The immobilization of ampicillin , chloramphenicol and 7-ACS depends on the reactivity of the carboxyl groups in the polymer, dicyclohexylcarbodiimide (DCC)/polymer molar ratio and reaction time. All obtained products possess antimicrobial activity.