Antibacterial structure—activity relationships obtained with resistant microorganisms I: Inhibition of R-factor resistant Escherichia coli by tetracyclines

Inhibition by paromomycin of R-factor tr

Inhibition by paromomycin of R-factor transfer of tetracycline resistance between Escherichia coli and Salmonella pullorum

✍ Aldo Buogo; Pierangelo Cattaneo 📂 Article 📅 1978 🏛 John Wiley and Sons 🌐 English ⚖ 414 KB

In vitro assays showed that low concentrations (5--10 and 20 microgram/ml) of the antimicrobial paromomycin sulfate are able to block or diminish significantly the transfer of the tetracycline resistance R-factor between Escherichia coli and Salmonella pullorum. This observation is important because