Inhibition by paromomycin of R-factor transfer of tetracycline resistance between Escherichia coli and Salmonella pullorum

✍ Scribed by Aldo Buogo; Pierangelo Cattaneo

• Publisher: John Wiley and Sons
• Year: 1978
• Tongue: English
• Weight: 414 KB
• Volume: 67
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600670110

✦ Synopsis

In vitro assays showed that low concentrations (5--10 and 20 microgram/ml) of the antimicrobial paromomycin sulfate are able to block or diminish significantly the transfer of the tetracycline resistance R-factor between Escherichia coli and Salmonella pullorum. This observation is important because it offers the possibility of preventing the formation of tetracycline-resistant pathogens, a limiting factor of tetracycline use in both human and veterinary medicine.