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Anti-topoisomerase I antibodies in systemic lupus erythematosus as a marker of severe nephritis

✍ Scribed by Mohamed A. Hamidou; Marie A. Audrain; Agathe Masseau; Christian Agard; Anne Moreau

Book ID
106264299
Publisher
Springer
Year
2006
Tongue
English
Weight
55 KB
Volume
25
Category
Article
ISSN
0770-3198

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Sera from patients with SLE frequently contain IgM and IgG antibodies with multiple specificities for lymphocyte surface determinants, including autologous antigens. The IgM antibodies are of relatively low binding avidity and exhibit broad reactivity with B and T lymphocytes from most individuals.