Anti-renal cell carcinoma chimeric antibody G250: cytokine enhancement of in vitro antibody-dependent cellular cytotoxicity
β Scribed by Zhanqi Liu, Fiona E. Smyth, Christoph Renner, Fook-Thean Lee, Egbert Oosterwijk, Andrew M. Scott
- Publisher
- Springer-Verlag
- Year
- 2002
- Tongue
- English
- Weight
- 146 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0340-7004
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
We have previously isolated and characterized 6 anti-idiotype antibodies (Ab2s) directed against monoclonal antibody G250 (MAbG250) which reacts with a tumor-associated antigen (TAA) expressed in a large proportion of human renal-cell carcinomas (RCC). These 6Ab2s (NUH31,51,71,82,91: IgG,, NUH44: Ig
An in vitro model of antibody-dependent cellular qtotoxicity (ADCC) was established, using squamous-cell carcinoma of the head and neck (SCCHN) targets, humanlmouse chimeric monoclonal adbodies (cMAbs) SF-25 and 323/A3 and human peripheral blood mononuclear cells (PBMC). We previously showed that na