Anti-p53 autoantibody in colorectal cancer: prognostic significance in long-term follow-up
β Scribed by A. Suppiah; A. Alabi; L. Madden; J. E. Hartley; J. R. T. Monson; J. Greenman
- Publisher
- Springer
- Year
- 2008
- Tongue
- English
- Weight
- 131 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0179-1958
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π SIMILAR VOLUMES
The overexpression of the tumor suppressor gene p53 was investigated immunohistochemically in 144 cases of primary colorectal cancer and in 8 cases with cancer in the corresponding metastatic lymph nodes. Abnormalities in p53 expression were found in 36 cases (25%) of the 144 primary cancer cases. I
## Abstract ## Background Cyclooxygenase (COX)β2 is believed to be an important enzyme related to the pathogenesis of colorectal cancer (CRC). p53 has been reported to be a negative regulator of COXβ2 expression in in vitro studies. The aim of this study was to investigate COXβ2 expression and its