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Anti-insulin-like growth factor-I activity of a novel polysulphonated distamycin A derivative in human lung cancer cell lines

✍ Scribed by Alessandra De Cupis; Marina Ciomei; Paolo Pirani; Alessandra Ferrera; Andrea Ardizzoni; Roberto Enrico Favoni

Book ID
110002739
Publisher
Nature Publishing Group
Year
1997
Tongue
English
Weight
600 KB
Volume
120
Category
Article
ISSN
0007-1188

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## Abstract Interaction of insulin‐like growth factor receptor I (IGF‐IR) with its ligands has been reported to induce cell proliferation, transformation and blockade of cell apoptotic functions. IGF‐IR is overexpressed on numerous tumor cell types and its blockade could be of importance for anti‐c