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Anti-inflammatory and anti-arthritic activities of 3,4-dihydro-2,2-dimethyl-2H-naphthol[1,2-b]pyran-5,6-dione (β-lapachone)

✍ Scribed by Marília Maria Sitônio, Carlson H. R. de Carvalho Júnior, Ingrid de A. Campos, José Bruno Nunes Ferreira Silva, Maria do Carmo Alves de Lima, Alexandre J. S. Góes, Maria Bernadete Sousa Maia, Pedro J. Rolim Neto, Teresinha G. Silva


Book ID
118777390
Publisher
SP Birkhäuser Verlag Basel
Year
2012
Tongue
English
Weight
262 KB
Volume
62
Category
Article
ISSN
1420-908X

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Abstmctz Dialkylation of the title compound occurs regioselectively at C-l. Addition of N,N'-diiethyl-NJ'-propylene urea (DMFV) permits the one-pot synthesis of I,l-dialkylation products in good yields. The asymmetric induction of the stereogenic C-4 center directs the first and the second alkylatio