Anti-idiotypic antibodies: what do they recognize?
β Scribed by B.F Erlanger
- Publisher
- Elsevier Science
- Year
- 1985
- Tongue
- English
- Weight
- 185 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0167-5699
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
There is accumulating evidence that cellular rather than antibody responses are more effective for tumour rejection. It is therefore important to screen anti-idiotypic (anti-id) antibodies for their ability to stimulate anti-tumour T-cell responses. The human anti-id monoclonal antibody (MAb) I05AD7
Anti-idiotypic antibodies that mimic tumour-associated antigens can stimulate anti-tumour T-cell responses. In this article, we have studied the role of Fc in the presentation of T-cell epitopes by 2 anti-idiotypic antibodies, 105AD7 and 708. The human monoclonal antibody 105AD7, which mimics CD55,