Anti-Hu-associated paraneoplastic sensory neuropathy and breast cancer
✍ Scribed by Siraj Bechich; Francesc Graus; Adrià Arboix; Albert Isidro; Margarita Martí; Francesc Rosell
- Publisher
- Springer
- Year
- 2000
- Tongue
- English
- Weight
- 524 KB
- Volume
- 247
- Category
- Article
- ISSN
- 0340-5354
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A patient with anti-Hu antibodies, small-cell lung carcinoma, and autopsy-proven subacute sensory neuropathy had early slowing of motor and sensory conduction velocities. In the peripheral nerves, chronic demyelinating and remyelinating lesions with axonal degeneration were associated with an inflam
Anti-Hu-associated paraneoplastic sensory neuropathy (PSN) has been reported to be nonresponsive to immunotherapy or cancer therapy. We report 2 patients with anti-Hu-associated PSN who achieved sustained clinical improvement with early and aggressive immunotherapy 10-15 months before the diagnosis