✦ LIBER ✦

Paraneoplastic demyelinating neuropathy, subacute sensory neuropathy, and anti-hu antibodies: Clinicopathological study of an autopsy case

✍ Scribed by Jean-Christophe Antoine; Jean-François Mosnier; Jérôme Honnorat; Philippe Convers; Léna Absi; Jérôme Lapras; Daniel Michel

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 622 KB
Volume: 21
Category: Article
ISSN: 0148-639X
DOI: 10.1002/(sici)1097-4598(199807)21:7<850::aid-mus2>3.0.co;2-5

No coin nor oath required. For personal study only.

✦ Synopsis

A patient with anti-Hu antibodies, small-cell lung carcinoma, and autopsy-proven subacute sensory neuropathy had early slowing of motor and sensory conduction velocities. In the peripheral nerves, chronic demyelinating and remyelinating lesions with axonal degeneration were associated with an inflammatory reaction consisting of CD8+ T cells and CD68+ macrophages. On immunohistochemical testing, the patient's serum did not react with normal nerve, suggesting that the Hu proteins were not the target of the inflammatory reaction in the nerve.

📜 SIMILAR VOLUMES

Utility of anti-Hu antibodies in the dia

Utility of anti-Hu antibodies in the diagnosis of paraneoplastic sensory neuropathy

✍ Jose Luis Molinuevo; Francesc Graus; Carmen Serrano; Ramón Reñe; Antonio Guerrer 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 516 KB

Clinicopathological study of an autopsy

Clinicopathological study of an autopsy case with sensory-dominant polyradiculoneuropathy with antiganglioside antibodies

✍ Tomokazu Obi; Toshikazu Murakami; Masami Takatsu; Susumu Kusunoki; Masahiro Seri 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 416 KB 👁 2 views

A previously reported patient presenting sensory-dominant neuropathy with antiganglioside antibodies, bound preferentially to polysialogangliosides including GD1b, was autopsied. While axonal degeneration was predominant in the sural nerve, many demyelinated fibers were present in the spinal roots.