Anti-HIV activity of flavonoids and proanthocyanidins from Crataegus sinaica

✍ Scribed by A.A. Shahat; S.I. Ismail; F.M. Hammouda; S.A. Azzam; G. Lemière; T. De Bruyne; S. De Swaef; L. Pieters; A. Vlietinck

• Book ID: 114307231
• Publisher: Elsevier Science
• Year: 1998
• Tongue: English
• Weight: 573 KB
• Volume: 5
• Category: Article
• ISSN: 0944-7113
• DOI: 10.1016/s0944-7113(98)80010-x

✦ Synopsis

In addition to quercetin, hyperoside, rutin, vitexin, 2"-O-rhamnosylvitexin, (4'"-O-acetyl)-2"-O-rhamnosylvitexin , epicatechin, procyanidin B-5, proanthocyanidin A-2, procyanidin B-2 and procyanidin C-1, which were reported before in Crataegus sinaica (Ro saceae), three more flavonoids were isolated from the same plant, i.e. (+ )-taxifolin, 3-0-~-arabinopyranosyl-( +)-taxifolin and 3-0-~-xylopyranosyl-(+)taxifolin. The in vitro anti-H IV activity of some selected flavonoids and proanthocyanidins was evaluated. The dimeric procyanidin B2 and proanthocyanidin A2, and especiall y the trimeric procyanidin C1 showed some in vitro anti-HfV activity.