Anti-HIV-1 activity, toxicity, and stability studies of representative structural families of polyoxometalates
β Scribed by Schinazi, Raymond F.; Hill, Craig L.; Weeks, Mark S.
- Book ID
- 111674113
- Publisher
- American Chemical Society
- Year
- 1990
- Tongue
- English
- Weight
- 862 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0022-2623
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The synthesis, in vitro anti-HIV activity and stability studies of the 5Π-fluorophosphate derivative of 3Π-azido-3Π-deoxythymidine (AZT) are reported. The results support the hypothesis that this phosphorylated entity exerts its biological effect via the delivery of the corresponding 5Π-mononucleoti
## Abstract **A novel series** of diarylpyrimidine analogues (DAPYs) featuring a naphthyl moiety at the C4 position were designed, with all compounds exhibiting strong activity against wildβtype HIVβ1.magnified image A novel series of diarylpyrimidine analogues (DAPYs) featuring a naphthyl moiety