Fatty acyl-glycol phosphate triester conjugates of 3 0 -fluoro-2 0 ,3 0 -dideoxythymidine (FLT) were prepared in three steps from the reaction of diisopropylphoramidous dichloride with fatty acyl-substituted glycols, followed by a coupling reaction with FLT and oxidation with tert-butyl hydroperoxid
✦ LIBER ✦
Synthesis, Anti-HIV Activity and Stability Studies of 3′-Azido-2′,3′-dideoxythymidine-5′-fluorophosphate
✍ Scribed by Egron, D.; Arzumanov, A. A.; Dyatkina, N. B.; Krayevsky, A.; Imbach, J-L.; Aubertin, A-M.; Gosselin, G.; Périgaud, C.
- Book ID
- 126729570
- Publisher
- Taylor and Francis Group
- Year
- 1999
- Tongue
- English
- Weight
- 121 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0732-8311
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## Abstract Methyl 3‐azido‐5‐__O‐tert__‐butyldiphenylsilyl‐2,3‐dideoxy‐D‐__erythro__‐furanoside (3) was coupled with silylated 5‐hydroxymethyluracil (1a) and its C~1~‐C~6~ alkyl ethers 1b–g to give the corresponding protected nucleosides 4a‐g which were deprotected with Bu~4~NF to afford 3‐azido nu
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