Anti-EGFR and ErbB-2 antibodies attenuate cyclooxygenase-2 expression and cooperatively inhibit survival of human colon cancer cells
โ Scribed by Elizabeth Half; Yunjie Sun; Frank A. Sinicrope
- Book ID
- 116334344
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 393 KB
- Volume
- 251
- Category
- Article
- ISSN
- 0304-3835
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Cyclooxygenase-2 (COX-2) over-expression is critically involved in tumor formation. Intracellular pH (pHi) has been shown to be alkaline in cancer cells, and to be an important trigger for cell proliferation. This study therefore analyzed the relationship between pHi and COX-2 expression. HRT-18 and
## Abstract A wealth of data implicates that ErbB receptors have essential roles in tumor development. Probiotic bacteria are known to exert an anticancer activity in animal studies. __Bacillus polyfermenticus__ (B.P.), a probiotic bacterium, has been clinically used for a variety of gastrointestin