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Triptolide Inhibits Cyclooxygenase-2 and Inducible Nitric Oxide Synthase Expression in Human Colon Cancer and Leukemia Cells

โœ Scribed by Xiangmin TONG; Shui'er ZHENG; Jie JIN; Lifen ZHU; Yinjun LOU; Hangping YAO


Book ID
111357745
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
614 KB
Volume
39
Category
Article
ISSN
1672-9145

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Cyclooxygenase-2 (COX-2) over-expression is critically involved in tumor formation. Intracellular pH (pHi) has been shown to be alkaline in cancer cells, and to be an important trigger for cell proliferation. This study therefore analyzed the relationship between pHi and COX-2 expression. HRT-18 and