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Anthracene and Anthraquinone Derivatives from the Stem Bark of Juglans mandshuricaMaxim.

✍ Scribed by Hua Lin; Yu-Wei Zhang; Li-Hua Zheng; Xiang-Ying Meng; Yong-Li Bao; Yin Wu; Chun-Lei Yu; Yan-Xin Huang; Yu-Xin Li

Publisher: John Wiley and Sons
Year: 2011
Tongue: German
Weight: 198 KB
Volume: 94
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.201000462

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✦ Synopsis

Abstract

One new anthracene derivative, juglanthracenoside A (1), two new anthraquinones, juglanthraquinone A (2) and juglanthraquinone B (3), along with a new naturally occurring anthraquinone, 9,10‐dihydro‐4,8‐dihydroxy‐9,10‐dioxoanthracene‐2‐carboxylic acid (4), have been isolated from the stem bark of Juglans mandshurica. Their structures were established by detailed spectroscopic analysis and comparison of the NMR data with those of related compounds. Compound 1 displayed noticeable antioxidant activity in both 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) and 2,2′‐azinobis(3‐ethylbenzothiazoline‐6‐sulfonic acid) (ABTS) free radical‐scavenging assays, while compound 4 showed strong cytotoxicity against HepG2, SGC7901, HCT‐8, and A549 cell lines in vitro.

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