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Anomalous expression of costimulatory molecules B7-1, B7-2 and CD28 in primary biliary cirrhosis

✍ Scribed by Ulrich Spengler; Ludger Leifeld; Ingrid Braunschweiger; Franz Ludwig Dumoulin; Martin Lechmann; Tilman Sauerbruch

Book ID
118567514
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
885 KB
Volume
26
Category
Article
ISSN
0168-8278

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Costimulation mediated by costimulatory molecules, such as B7-1 and B7-2, which are ligands for the CD28/cytolytic T lymphocyte associated antigen (CTLA)-4 counter-receptor, plays an important role in the induction of T cell-mediated antitumor immunity. We investigated the expressions of B7-1, B7-2,