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Expression of costimulatory molecules B7/CD28 in systemic lupus erythematosus

✍ Scribed by Hu Shaoxian; Tao Deding; He Peigen


Publisher
Springer-Verlag
Year
2004
Tongue
Chinese
Weight
286 KB
Volume
24
Category
Article
ISSN
0510-9752

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Costimulation mediated by costimulatory molecules, such as B7-1 and B7-2, which are ligands for the CD28/cytolytic T lymphocyte associated antigen (CTLA)-4 counter-receptor, plays an important role in the induction of T cell-mediated antitumor immunity. We investigated the expressions of B7-1, B7-2,

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## Abstract This study attempted to estimate soluble CD4(sCD4)/CD8(sCD8) molecules in active systemic lupus erythematosus (SLE) patients. Measurements were made by solid‐phase enzyme‐linked immunosorbent assay. sCD8 or sCD4 molecules were significantly increased in the patients as compared to contr