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Anomalous cellular proliferation in vitro associated with Huntington's disease

✍ Scribed by David Kirk; Jennifer M. Parrington; Gerald Corney; Jean M. W. Bolt

Publisher
Springer
Year
1977
Tongue
English
Weight
537 KB
Volume
36
Category
Article
ISSN
0340-6717

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✦ Synopsis

Detailed growth analyses of cultured skin fibroblasts from two patients with Huntington's Disease (HD) were compared with those from controls matched for age and sex. In contrast to control cells, HD fibroblasts plated more efficiently at the low seeding densities used. Subsequent exponential growth of HD cultures was more stable towards routine trypsinisation than that of controls. However, the most striking feature of HD cultures was their ability to grow to significantly higher cell saturation densities. Experiments with trypsinised and untrypsinised cultures imply an inherent alteration in the HD cell membrane.

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