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Anodic oxidation reactions: the total synthesis of (+)-nemorensic acid

โœ Scribed by Bin Liu; Kevin D Moeller


Book ID
104231555
Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
62 KB
Volume
42
Category
Article
ISSN
0040-4039

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โœฆ Synopsis


The anodic coupling of an enol ether to an oxygen nucleophile has been used as a key step in the total synthesis of (+)-nemorensic acid. The anodic cyclization reaction allows for a reversal in the way the tetrahydrofuran ring of the natural product is normally assembled and thus enables construction of the ring in a highly stereoselective fashion.


๐Ÿ“œ SIMILAR VOLUMES


Anodic cyclization reactions and the syn
โœ Hai-Chao Xu; John D. Brandt; Kevin D. Moeller ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 112 KB

A synthesis of (ร€)-crobarbatic acid is reported along with the first use of a vinyl-substituted ketene dithioacetal as a coupling partner for an anodic cyclization reaction. The use of the vinyl-substituted ketene dithioacetal enables the construction of a cyclic product having a tetrasubstituted ca