We studied mathematical models for the length distributions of actin filaments under the effects of polymerization/depolymerization, and fragmentation. In this paper, we emphasize the effects of these two processes acting alone. In this case, simple discrete and continuous models can be derived and
Annealing Accounts for the Length of Actin Filaments Formed by Spontaneous Polymerization
β Scribed by Sept, David; Xu, Jingyuan; Pollard, Thomas D.; Andrew McCammon, J.
- Book ID
- 119412113
- Publisher
- Biophysical Society
- Year
- 1999
- Tongue
- English
- Weight
- 240 KB
- Volume
- 77
- Category
- Article
- ISSN
- 0006-3495
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π SIMILAR VOLUMES
In a previous paper, we studied elementary models for polymerization, depolymerization, and fragmentation of actin filaments (Edelstein-Keshet and Ermentrout, 1988, Bull. Math. Biol. 60, 449-475). When these processes act together, more complicated dynamics occur. We concentrate on a particular case
During actin polymerization, it has been theorized that the actin filament length distribution initially grows in the form of a Gaussian before converting to produce that of an exponential. However, it has been difficult to demonstrate this experimentally. In this study, we use modern fluorescence m