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Models for the Length Distributions of Actin Filaments: II. Polymerization and Fragmentation by Gelsolin Acting Together

✍ Scribed by G.Bard Ermentrout; Leah Edelstein-Keshet

Publisher: Springer
Year: 1998
Tongue: English
Weight: 319 KB
Volume: 60
Category: Article
ISSN: 1522-9602
DOI: 10.1006/bulm.1997.0012

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✦ Synopsis

In a previous paper, we studied elementary models for polymerization, depolymerization, and fragmentation of actin filaments (Edelstein-Keshet and Ermentrout, 1988, Bull. Math. Biol. 60, 449-475). When these processes act together, more complicated dynamics occur. We concentrate on a particular case study, using the actin-fragmenting protein gelsolin. A set of biological parameter values (drawn from the experimental literature) is used in computer simulations of the kinetics of gelsolin-mediated actin filament fragmentation.

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Models for the Length Distributions of Actin Filaments: I. Simple Polymerization and Fragmentation

✍ Leah Edelstein-Keshet; G.Bard Ermentrout 📂 Article 📅 1998 🏛 Springer 🌐 English ⚖ 300 KB

We studied mathematical models for the length distributions of actin filaments under the effects of polymerization/depolymerization, and fragmentation. In this paper, we emphasize the effects of these two processes acting alone. In this case, simple discrete and continuous models can be derived and