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Anisomycin treatment enhances TRAIL-mediated apoptosis in renal carcinoma cells through the down-regulation of Bcl-2, c-FLIP(L) and Mcl-1

✍ Scribed by Seo, Bo Ram; Min, Kyoung-jin; Kim, Shin; Park, Jong-Wook; Park, Won-Kyun; Lee, Tae-Jin; Kwon, Taeg Kyu

Book ID: 122717669
Publisher: Elsevier Science
Year: 2013
Tongue: English
Weight: 997 KB
Volume: 95
Category: Article
ISSN: 0300-9084
DOI: 10.1016/j.biochi.2012.12.002

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## Abstract Renal cell carcinoma (RCC) is one of the most drug‐resistant malignancies in humans. We show that adriamycin (ADR) and TNF‐related apoptosis‐inducing ligand (TRAIL)/Apo2L have a synergistic cytotoxic effect against RCC cells. This synergistic cytotoxicity was obtained in ACHN, A704, Cak