Animal Models of Parkinsonism
✍ Scribed by Kaakkola, Seppo ;Teräväinen, Heikki
- Book ID
- 114801476
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 674 KB
- Volume
- 67
- Category
- Article
- ISSN
- 0901-9928
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PHNO, a naphthoxazine compound, was investigated in animal models of central dopaminergic activity. The drug in doses of 5-300 micrograms/kg when administered subcutaneously, or transdermally, induced stereotypic behavior in rats which was blocked by haloperidol but not by reserpine pretreatment. In
## Abstract Animal models are important tools in experimental medical science to better understand pathogenesis of human diseases. Once developed, these models can be exploited to test therapeutic approaches for treating functional disturbances observed in the disease of interest. On the basis of e