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Animal Models of Movement Disorders || Utility of 6-Hydroxydopamine Lesioned Rats in the Preclinical Screening of Novel Treatments for Parkinson Disease

✍ Scribed by Cenci, M. Angela


Book ID
120937283
Publisher
Elsevier
Year
2005
Weight
331 KB
Category
Article
ISBN
0120883821

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## Abstract To investigate the psychiatric symptoms accompanying the early phases of Parkinson's disease (PD), we injected adult rats with 10.5 μg 6‐hydroxydopamine (6‐OHDA) bilaterally into the dorsal striatum. The resulting neurodegeneration led, 12 weeks after injection, to a mild (36%) reductio