𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Angiopoietin-2 decreases vascular endothelial growth factor expression by modulating HIF-1α levels in gliomas

✍ Scribed by Lee, O-H; Xu, J; Fueyo, J; Alonso, M M; Liu, D; Martin, V; Jiang, H; Piao, Y; Liu, T J; Gomez-Manzano, C


Book ID
110072721
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
208 KB
Volume
27
Category
Article
ISSN
0950-9232

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Physical and functional interactions bet
✍ Tae-Geon Kwon; Xiang Zhao; Qian Yang; Yan Li; Chunxi Ge; Guisheng Zhao; Renny T. 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 718 KB

Angiogenesis and bone formation are intimately related processes. Hypoxia during early bone development stabilizes hypoxia-inducible factor-1α (HIF-1α) and increases angiogenic signals including vascular endothelial growth factor (VEGF). Furthermore, stabilization of HIF-1α by genetic or chemical me

2-oxoglutarate downregulates expression
✍ Ken Matsumoto; Shigehiko Imagawa; Naoshi Obara; Norio Suzuki; Satoru Takahashi; 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 299 KB

## Abstract In oxygenated cells, hypoxia‐inducible factor‐1 (HIF‐1) α subunits are rapidly degraded by a mechanism that involves ubiquitination by the von Hippel–Lindau tumor suppressor E3 ligase complex using 2‐oxoglutarate as a substrate. We examined the effect of 2‐oxoglutarate on the production