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Angiogenic factors: syntheses of 12(R)- and 12(S)-hydroxyeicosa-5(Z),8(Z),14(Z)-trienoic acid and their 14,15-dehydro analogs

✍ Scribed by Kamlesh Chauhan; Dhamjewar Ravi; J.R. Falck; Robert A. Stoltz; Michal Laniado-Schwartzman


Book ID
108476982
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
261 KB
Volume
4
Category
Article
ISSN
0960-894X

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✍ Thierry Eynard; Jean-Michel VatΓ¨le; Didier Poullain; Jean-Pierre NoΓ«l; Jean-Mich πŸ“‚ Article πŸ“… 1994 πŸ› Elsevier Science 🌐 English βš– 743 KB

In order to study the effect of the double bonds geometry of linolenic acid (18:3 n-3) on its biological activities, (gz,12Z, I 5E)-and (9E, I 2Z, 15Z)-octadecatrienoic acids, found in many refined vegetable oils, were made by total synthesis. Synthesis of 18:3 A9c, 12c, 1St involves a Wittig reacti