Angiogenesis: Models, Modulators, and Clinical Applications

✍ Scribed by Michael E. Maragoudakis (auth.), Michael E. Maragoudakis (eds.)

• Publisher: Springer US
• Year: 1998
• Tongue: English
• Leaves: 552
• Series: NATO ASI Series 298
• Edition: 1
• Category: Library

✦ Synopsis

Interest in angiogenesis research remains strong in recent years and exciting new discoveries, about modulators of angiogenesis, their receptors, the transduction mechanisms and the angiogenic genes involved, have contributed to our present day understanding of this complex process. This knowledge has provided the basis and broadened the scope of angiogenesis - based therapy in oncology and many other clinical conditions. This monograph contains the contributions to the NATO Advanced Study Institute on "Angiogenesis: Models, Modulators and Clinical Applications", which was held in Rhodes, Greece, from June 20-30, 1997. This was the fourth of a series of NATO supported international meetings on Angiogenesis aiming to bring together basic scientists with clinicians to exchange ideas, disseminate new knowledge and discuss the present status and potential new directions in this fast moving area of biomedical research. The International Organising Committee that included Drs. E. Dejana, C Haudenschild, M. Hackel, H. Kleinman, P. Lelkes, M. Presta, P. Polverini, D. Thompson, has provided invaluable help with their insightful suggestions in the formulation of the scientific program for which I am grateful. I wish to thank all the participants for their enthusiastic participation and their complimentary comments on the success of the conference.

✦ Table of Contents

Front Matter....Pages i-x
Introductory Comments....Pages 1-4
Front Matter....Pages 5-5
Microvascular Endothelial Cells from Adrenal Medulla — A Model for in Vitro Angiogenesis....Pages 7-18
Angiogenesis in the Heart and Skeletal Muscle — Models for Capillary Growth....Pages 19-33
Basement Membrane Biosynthesis as a Biochemical Index of Angiogenesis in Chick Chorioallantoic Membrane....Pages 35-38
The Rat and the Rabbit Cornea Assay....Pages 39-46
The Rat Aorta Model of Angiogenesis: Methodology and Applications....Pages 47-53
Assessment of Angiogenesis by MRI....Pages 55-60
Measuring Intratumoral Microvessel Density....Pages 61-74
Patterns of Physiological Angiogenesis in Adult Mesentery....Pages 75-84
Angiogenesis — Critical Assessment of in-Vitro Assays and in — Vivo Models....Pages 85-89
Front Matter....Pages 91-91
The Several Roles for Oxygen in Wound Angiogenesis....Pages 93-98
Autocrine Role of Basic Fibroblast Growth Factor (bFGF) in Angiogenesis and Angioproliferative Diseases....Pages 99-112
Inflammatory Angiogenic Factors in a Model of Chronic Inflammation....Pages 113-120
Angiogenic Mediators in Wound Healing....Pages 121-128
Modulation of Vascular Endothelial Growth Factor Angiogenic Activity by ADP-Ribosylation....Pages 129-135
Role of Fibroblast Growth Factor -2 and Endothelial Cell Stimulating Angiogenic Factor (ESAF) in Capillary Growth in Skeletal Muscles Exposed to Long-Term High Activity....Pages 137-147
Angiogenesis in Atherosclerosis: Possible Roles for Vascular Endothelial Cell Growth Factor, Endothelial Cell Stimulating Angiogenesis Factor and Soluble E-Selectin....Pages 149-155
Thymosin Beta 4 Promotes Endothelial Cell Migration and Angiogenesis....Pages 157-163
Structural Studies on Angiogenin, a Protein Implicated in Neovascularization during Tumour Growth....Pages 165-178
Lesional Levels of Endothelial Cell Stimulating Angiogenesis Factor (ESAF) and Vascular Endothelial Cell Stimulating Angiogenesis Factor (VEGF) are Elevated in Psoriasis....Pages 179-184
Front Matter....Pages 185-185
Structure and Functional Role of Endothelial Cell-to-Cell Junctions....Pages 187-201
The Interaction of Human Neutrophils with Type IV Collagen Involves an Inhibitory Signal Transduction Pathway....Pages 203-211
Angiogenic Polypeptides in Breast Cancer: Expression of Mrna’s in Primary Human Tumours, MCF-7 Cell Transfection and Xenograft Models....Pages 213-221
Front Matter....Pages 223-223
The Role of Thrombin and Its Receptors in Angiogenesis. Physiological and Pathological Applications....Pages 225-232
Fibrin Degradative Pathways and Angiogenesis in Healing, Atherosclerosis and Tumour Invasion....Pages 233-240
Proteases and Angiogenesis. Regulation of Plasminogen Activators and Matrix Metalloproteases by Endothelial Cells....Pages 241-261
Cellular and Molecular Effects of Thrombin in the Vascular System....Pages 263-282
Front Matter....Pages 283-283
Endogenous Regulation of Angiogenesis in Vitro ....Pages 285-296
Nitric Oxide and Angiogenesis....Pages 297-306
Nitric Oxide: A Promoter or Inhibitor of Angiogenesis....Pages 307-319
Hypoxia/Reoxygenation Enhances Tube Formation of Cultured Human Microvascular Endothelial Cells: the Role of Reactive Oxygen Species....Pages 321-336
Tumour Angiogenesis and Metastasis: The Regulatory Role of Hyaluronan and Its Degradation Products....Pages 337-347
Cytokines and Growth Factors. Early Gene Expression During Angiogenic Stimuli....Pages 349-353
The Role of the Laminin Peptide SIKVAV in the Revascularization of Ischemic Tissue....Pages 355-365
Oxidized Lipoproteins Enhance the in Vitro Tube Formation by Endothelial Cells Cultured on Matrigel....Pages 367-375
A Peptied From the NC1 Domain of the α3 Chain of Type IV Collagen Prevents Damage to Basement Membranes by PMN....Pages 377-386
Front Matter....Pages 387-387
Tumoral Vascularity: What Does It Tell Us About the Growth and Spread of Cancer?....Pages 389-405
Tumor Vascularity, Hypoxia, and Malignant Progression in Solid Neoplasms....Pages 407-414
Scatter Factor as a Mediator of Tumor Angiogenesis....Pages 415-426
Front Matter....Pages 427-427
The Vascularization of Experimental and Human Primary Tumors: Comparative Morphometric and Morphologic Studies....Pages 429-447
Front Matter....Pages 427-427
“CM101 — An Anti-Pathoangiogenic Agent: Pre-Clinical and Clinical Experiences”....Pages 449-457
Mapping Neovascularization and Antineovascularization Therapy....Pages 459-473
Clinical Trials of Angiogenesis-Based Therapies: Overview and New Guiding Principles....Pages 475-492
Abstracts of Posters....Pages 493-557
Back Matter....Pages 558-571

✦ Subjects

Oncology; Pharmacology/Toxicology