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Angiogenesis inhibition augments the effect of imatinib in gastrointestinal stromal tumor

✍ Scribed by Cohen, Noah A.; Zeng, Shan; Kim, Teresa S.; Cavnar, Michael J.; Seifert, Adrian M.; Sorenson, Eric C.; Greer, Jonathan B.; Crawley, Megan H.; Green, Benjamin L.; DeMatteo, Ronald P.

Book ID
122006331
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
41 KB
Volume
217
Category
Article
ISSN
1072-7515

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## Abstract Mutations of proto‐oncogene c‐KIT in gastrointestinal stromal tumors (GISTs) are considered to cause a constitutive activation of KIT responsible for their oncogenesis. Imatinib has therapeutic potential for GISTs because of its inhibitory effect on KIT kinase activity. To investigate t