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Anencephaly in trisomy 18 associated with elevated alpha-1-fetoprotein in amniotic fluid

✍ Scribed by Ulrik Merrild; Vibeke Schiøler; Flemming Christensen; Ewald Wolny; Carl Johan Edeling

Book ID
104699892
Publisher
Springer
Year
1978
Tongue
English
Weight
239 KB
Volume
45
Category
Article
ISSN
0340-6717

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✦ Synopsis

Elevated levels of alpha-1-fetoprotein (AFP) were found in the amniotic fluid of a 36-year-old woman in the 15th week of gestation. Because of this and the results of repeated ultrasonography, abortion was induced. An anencephalic fetus with trisomy 18 was delivered. The possible correlation among neural-tube defects, chromosomal abnormalities, and level of AFP is discussed.

📜 SIMILAR VOLUMES

ELEVATED MATERNAL SERUM AND AMNIOTIC FLU
ELEVATED MATERNAL SERUM AND AMNIOTIC FLUID ALPHA-FETOPROTEIN LEVELS IN THE DENYS–DRASH SYNDROME
✍ KOENRAAD DEVRIENDT; KAMIEL VAN DEN BERGHE; PHILIPPE MOERMAN; JEAN-PIERRE FRYNS 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 237 KB 👁 2 views

We report the findings in a child with the Denys-Drash syndrome presenting prenatally with a diaphragmatic hernia, male pseudohermaphroditism, and elevated alpha-fetoprotein levels in amniotic fluid and in maternal serum.

High amniotic fluid alpha-1-fetoprotein
High amniotic fluid alpha-1-fetoprotein in a case of fetal sacrococcygeal teratoma
✍ W. Schmid; J. P. Mühlethaler 📂 Article 📅 1975 🏛 Springer 🌐 English ⚖ 127 KB

Amniocentesis was performed in a pregnancy of 26 weeks because of hydramnios. The amniotic fluid was examined for fetal karyotype and AFP content. The latter was elevated to 300 mug/ml. Fetal death occurred shortly after amniocentesis and a malformed male fetus with a large sacrococcygeal teratoma w