Investigation of the coordinated functio
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Christine D.H. Tran; Peter Timmins; Barbara R. Conway; William J. Irwin
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Article
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2002
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John Wiley and Sons
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English
β 233 KB
The coordination of the functional activities of intestinal CYP3A4 and P-gp in limiting the absorption of xenobiotics in Caco-2 cells was investigated. Growing Caco-2 cells were exposed to increasing concentrations of doxorubicin (1Β±2 mM) in plastic Β―asks to encourage a subpopulation of cells, that