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Andrographolide inhibits the expression and metabolic activity of cytochrome P450 3A4 in the modified Caco-2 cells

✍ Scribed by Feng Qiu; Xiao-Long Hou; Kyoko Takahashi; Li-Xia Chen; Junichi Azuma; Ning Kang


Book ID
116645569
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
359 KB
Volume
141
Category
Article
ISSN
0378-8741

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The coordination of the functional activities of intestinal CYP3A4 and P-gp in limiting the absorption of xenobiotics in Caco-2 cells was investigated. Growing Caco-2 cells were exposed to increasing concentrations of doxorubicin (1Β±2 mM) in plastic Β―asks to encourage a subpopulation of cells, that