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Gene Expression Profiles of ABC Transporters and Cytochrome P450 3A in Caco-2 and Human Colorectal Cancer Cell Lines

✍ Scribed by Tsutomu Nakamura; Toshiyuki Sakaeda; Nobuko Ohmoto; Yuka Moriya; Chiho Komoto; Toshiro Shirakawa; Akinobu Gotoh; Masafumi Matsuo; Katsuhiko Okumura


Book ID
110416688
Publisher
Springer US
Year
2003
Tongue
English
Weight
73 KB
Volume
20
Category
Article
ISSN
0724-8741

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The coordination of the functional activities of intestinal CYP3A4 and P-gp in limiting the absorption of xenobiotics in Caco-2 cells was investigated. Growing Caco-2 cells were exposed to increasing concentrations of doxorubicin (1Β±2 mM) in plastic Β―asks to encourage a subpopulation of cells, that