## Background A crucial event in Prostate Cancer progression is the conversion from a hormone-sensitive to a hormone-refractory disease state. Correlating with this transition, androgen receptor (AR) amplification and mutations are often observed in patients failing hormonal ablation therapies. ฮฒ-C
Androgens stimulate endothelial progenitor cells through an androgen receptor-mediated pathway
โ Scribed by Carlo Foresta; Daniela Zuccarello; Luca De Toni; Andrea Garolla; Nicola Caretta; Alberto Ferlin
- Book ID
- 108703921
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 614 KB
- Volume
- 0
- Category
- Article
- ISSN
- 0300-0664
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract Androgen and androgen receptor (AR) are involved in growth of normal prostate and development of prostatic diseases including prostate cancer. Androgen deprivation therapy is used for treating advanced prostate cancer. This therapeutic approach focuses on suppressing the accumulation of
Prostaglandin E 2 (PGE 2 ) has been shown to induce expression of vascular endothelial growth factor (VEGF) and other signaling molecules in several cancers. PGE 2 elicits its functions though four G-protein coupled membrane receptors (EP1-4). In this study, we investigated the role of EP receptors