Isosilybin B causes androgen receptor degradation in human prostate carcinoma cells via PI3K-Akt-Mdm2-mediated pathway

Isosilybin A induces apoptosis in human

Isosilybin A induces apoptosis in human prostate cancer cells via targeting Akt, NF-κB, and androgen receptor signaling

✍ Gagan Deep; Subhash C. Gangar; Nicholas H. Oberlies; David J. Kroll; Rajesh Agar 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 382 KB

## Abstract Prostate cancer (PCA) is the second most malignancy in American men. Advanced stage PCA cells possess unlimited replication potential as well as resistance to apoptosis. Therefore, targeting survival mechanisms and activating apoptotic machinery in PCA cells using nontoxic phytochemical