Prostate cancer is considered to be one of the most hormone-dependent human malignancies. As a key mediator of hormonal response, the androgen receptor (AR) is believed to have an important role in the progression of prostate cancer. Mutations in the coding region of the AR gene have been found in b
β¦ LIBER β¦
Androgen Receptor Mutations in High-Grade Prostate Cancer before Hormonal Therapy
β Scribed by Thompson, J.
- Book ID
- 110087179
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 534 KB
- Volume
- 83
- Category
- Article
- ISSN
- 0023-6837
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Despite the initial androgen-dependent growth of most human prostate cancers, eventually all prostate cancers become androgen-independent at varying intervals after androgen ablation or anti-androgen therapy. In order to gain more insight into the role of the androgen receptor (AR) in this process,