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Androgen receptor gene haplotype is associated with male infertility

✍ Scribed by M. Saare; A. Belousova; M. Punab; M. Peters; K. Haller; K. Ausmees; O. Poolamets; H. Karro; A. Metspalu; A. Salumets


Book ID
108785352
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
124 KB
Volume
31
Category
Article
ISSN
0105-6263

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Mutations in the androgen receptor (AR) gene result in androgen insensitivity syndrome (AIS). We have identified five novel mutations that result in a complete loss in AR function and are associated with complete AIS. The mutations span all three AR major functional domains. In two cases, the loss o