Androgen Receptor and E2F-1 Targeted Thymoquinone Therapy for Hormone-Refractory Prostate Cancer
β Scribed by Kaseb, A. O.; Chinnakannu, K.; Chen, D.; Sivanandam, A.; Tejwani, S.; Menon, M.; Dou, Q. P.; Reddy, G. P.-V.
- Book ID
- 121687235
- Publisher
- American Association for Cancer Research
- Year
- 2007
- Tongue
- English
- Weight
- 462 KB
- Volume
- 67
- Category
- Article
- ISSN
- 0008-5472
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Prostate cancer is considered to be one of the most hormone-dependent human malignancies. As a key mediator of hormonal response, the androgen receptor (AR) is believed to have an important role in the progression of prostate cancer. Mutations in the coding region of the AR gene have been found in b
## Abstract The antiβandrogens used in prostate cancer therapy have been designed to interfere with the normal androgen receptor (AR)βmediated processes that ensure prostate cell survival, triggering tumor cells to undergo programmed cell death. While antiβandrogens were originally designed to trea