## Abstract The androgen receptor (AR) is involved in the development and maintenance of the normal prostate and the development and progression of prostate cancer (PCa). Caveolinβ1 (cavβ1) is an AR coβregulator. The expression of this integral membrane protein is upregulated in PCa and correlates
Androgen receptor and caveolin-1 in prostate cancer
β Scribed by Nigel Bennett; John D. Hooper; C. Soon Lee; Glenda C. Gobe
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 98 KB
- Volume
- 61
- Category
- Article
- ISSN
- 1521-6543
- DOI
- 10.1002/iub.260
No coin nor oath required. For personal study only.
β¦ Synopsis
Abstract
Flow diagram of androgen, androgen receptor and caveolinβ1 activity. See Androgen Receptor and Caveolinβ1 in Prostate Cancer by Bennett et al., pp. 961β970.
π SIMILAR VOLUMES
BACKGROUND. Increased expression of caveolin has been associated with prostate cancer progression. In a mouse reconstitution model of prostate cancer, expression of caveolin was inversely related to androgen sensitivity: androgen independent clones had high caveolin expression; low caveolin expressi
## Abstract The importance of androgens and androgen receptors (AR) in primary prostate cancer is well established. Metastatic disease is usually treated with some form of androgen ablation, which is effective for a limited amount of time. The role of AR in prostate cancers that recur despite andro
Prostate cancer is considered to be one of the most hormone-dependent human malignancies. As a key mediator of hormonal response, the androgen receptor (AR) is believed to have an important role in the progression of prostate cancer. Mutations in the coding region of the AR gene have been found in b
## Abstract Endocrine therapy for advanced prostate cancer is based on androgen ablation or blockade of the androgen receptor (AR). AR action in prostate cancer has been investigated in a number of cell lines, their derivatives, and transgenic animals. AR expression is heterogenous in prostate canc