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Anatomic and Disease Specificity of NADH CoQ1 Reductase (Complex I) Deficiency in Parkinson's Disease

โœ Scribed by A. H. V. Schapira; V. M. Mann; J. M. Cooper; D. Dexter; S. E. Daniel; P. Jenner; J. B. Clark; C. D. Marsden

Book ID
111175870
Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
362 KB
Volume
55
Category
Article
ISSN
0022-3042

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โœ J. M. Cooper; S. E. Daniel; C. D. Marsden; Prof. A. H. V. Schapira ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 305 KB

There is evidence for a 37% deficiency of complex I activity in Parkinson's disease (PD), which appears to be specific for PD amongst parkinsonian syndromes and selective for the substantia nigra within the central nervous system. Rat studies have shown that, in the context of a normal nigrostriatal